Tumor Antigen Escape from CAR T-cell Therapy
نویسندگان
چکیده
منابع مشابه
Overcoming Antigen Escape with CAR T-cell Therapy.
Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies.
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2018
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-18-0442